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88058
Tigecycline
Activators & Inhibitors
Chemical Modulators

Tigecycline #88058

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Chemical structure of Tigecycline.

Product Usage Information

Tigecycline is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 10 mg of powder in 1.13 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight: 585.7 g/mol

Purity: >98%

Molecular Formula: C29H39N5O8

CAS: 220620-09-7

Solubility: Soluble in DMSO at 25 mg/ml.

Background

Tigecycline, also known as GAR-936, is a broad spectrum glycylcycline antimicrobial that binds to the bacterial 30S ribosome, blocking the entry of transfer RNA. This prevents protein synthesis and limits bacterial growth. Tigecycline has a 9-t-butyl-glycylamido side chain on the central skeleton, giving it the ability to overcome most tetracycline resistance mechanisms (1). In vitro studies have shown that Tigecycline has activity against multidrug-resistant Gram-negative and -positive bacteria, vancomycin-resistant enterococci (VRE), methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis (MRSE), and penicillin-resistant Streptococcus (1,2). Studies have also found that Tigecycline can selectively kill human leukemia stem and progenitor cells with no disruption to normal hematopoietic cells (3). This small compound has been shown to induce apoptosis and inhibit cell proliferation in cervical cancers by suppressing the Wnt/β-catenin signaling pathway (4).

  1. Pankey, G.A. (2005) J Antimicrob Chemother 56, 470-80.
  2. Greer, N.D. (2006) Proc (Bayl Univ Med Cent) 19, 155-61.
  3. Skrtić, M. et al. (2011) Cancer Cell 20, 674-88.
  4. Li, H. et al. (2015) Biochem Biophys Res Commun 467, 14-20.
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

To Purchase # 88058S
Product # Size Price
88058S
10 mg N/A

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